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Vaccination in pediatric SOT: ERN TransplantChild recommendations
Evidence-based recommendations on vaccination in pediatric solid organ transplant (SOT) candidates and recipients were developed by the European Reference Network (ERN) TransplantChild Working Group and published in the Journal of Pediatric Gastroenterology and Nutrition by Casotti et al.
Key data: Pediatric SOT candidates should receive the broadest possible age- and organ-appropriate vaccination coverage before serious complications of chronic organ insufficiency arise. Live-attenuated vaccines (LAVs) should be administered at least 4 weeks and inactivated vaccines at least 2 weeks before SOT. Accelerated vaccination schedules are strongly recommended when needed for candidates approaching transplantation. A multidisciplinary approach, involving transplant specialists, immunologists, and infectious disease specialists, is recommended to support timely vaccination and ongoing protection against infection pre- and post-transplant.
Key learning: This position paper provides recommendations for optimizing vaccination in pediatric SOT candidates and recipients, emphasizing timely pre-transplant immunization, individualized vaccination strategies, and multidisciplinary coordination to help reduce the burden of vaccine-preventable infections.
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