ILTS-iLDLT consensus conference guidelines for long-term care of living liver donors

Guidelines from the 2025 International Liver Transplantation Society and International Living Donor Liver Transplantation Society (ILTS-iLDLT) consensus conference on long-term considerations following living donor liver transplantation (LDLT) were published in Liver Transplantation by Rammohan et al. The guidelines outline 11 recommendations across three key areas: long-term follow-up protocols, management of late surgical complications, and long-term psychosocial and ethical considerations. 

Key data: Recommendations include regular follow-up for up to 2 years post-hepatectomy, with visits at 1, 3, 6, 12, and 24 months. Donors at risk for late biliary complications should receive education and close monitoring, with identified biliary strictures investigated and treated at the transplant center. Comprehensive, multidisciplinary evaluations should be conducted to identify physical, psychological, and socioeconomic factors predisposing donors to poor long-term health-related quality of life (HRQoL). Donors should also receive structured financial counseling and routine psychosocial follow-up, including standardized screening for depression, anxiety, suicidality, and post-donation regret. 

Key learning: Living liver donors should undergo comprehensive, multidisciplinary, long-term follow-up to safeguard their health and optimize their outcomes.